This is the 2018 edition of the antimicrobial guidelines prepared by antimicrobial stewardship technical subcommittee under National Antimicrobial Resistance committee (AMR). The current edition is aimed at guiding physicians who practice across different levels of healthcare acuity to select appropriate empirical antibiotics for treatment of common community & healthcare associated infections. Guidelines are considered supplementary strategy of antimicrobial stewardship and is most helpful in hospitals who lack infectious diseases expertise or stewardship team.